Studies in Rh Sensitization

By ALEXANDER S. WIENER, M.D., F.A.C.P., RAFFAELE NAPPI, M.D. AND EVE B. GORDON I N THE PRECEDING PAPER’ our methods for performing Rh antibody titrations were described in detail, with special reference to the precautions taken to insure objective and reproducible results. Using these technics, it was shown that pregnancies with Rh-negative fetuses and the birth of Rh-negative babies have no significant effect on the Rh antibody titer of sensitized Rh-negative mothers. This paper is a continuation of these studies on Rh sensitization and will present the results of observations on the effect of pregnancies with Rhpositive fetuses and birth of Rh-positive babies on the maternal Rh antibody titer. As will be pointed out, these findings have important implications with regard to the frequency with which pregnant Rh-negative women are apt to be-